Fuente
Este artículo es originalmente publicado en:
http://www.ncbi.nlm.nih.gov/pubmed/24706308
http://www.europeanreview.org/article/7145
De:
Fan XL1, Han ZJ, Gong XY, Xiang JJ, Zhu LL, Chen WH.
Eur Rev Med Pharmacol Sci. 2014;18(6):840-5.
Todos los derechos reservados para:
Copyright © 1997-2014 European Review for Medical and Pharmacological Sciences
Abstract
AIM:
To explore the value of morphological classification in predicting malignant transformation in multiple exostoses (ME).
PATIENTS AND METHODS:
The imaging data of 116 patients (totally 190 tumors) with ME were retrospectively analyzed. All the tumors were pathology confirmed after surgical resection, including 175 exostoses from 101 patients, and 15 exostotic chondrosarcomas in 15 cases. Based on the ratio of diameter between tumor tip and tumor base (R1), tumors were classified into two types: cauliflower-like tumor (R1 ≥ 1.0) and non-cauliflower-like tumor (R1 < 1.0). In addition, non-cauliflower-like tumors were further classified into two subtypes according to the ratio of tumor height to tumor base diameter: sessile type (R2 < 1.0) and pedunculated type (R2 ≥ 1.0). The relationship between tumor shape and malignant transformation was studied.
RESULTS:
Of all the 175 exostoses from 101 patients, 27 were cauliflower-like tumors and 148 were non-cauliflower-like tumors. Of all the 15 exostotic chondrosarcomas in 15 cases, most tumors were cauliflower-like (c2 = 38.0075, p < 0.05). Cauliflower-like tumor for the prediction of exostotic chondrosarcoma, the sensibility, specificity, positive predictive value, negative predictive value were 86.7%, 84.6%, 32.5%, 98.7%, respectively.
CONCLUSIONS:
Tumor malignant transformation was more common in cauliflower-like tumors than in non-cauliflower-like tumors. The morphological classification and preventive resection of cauliflower-like tumors maybe helpful in preventing the malignant transformation of ME.
Resumen
AIM:
Para explorar el valor de clasificación morfológica en la predicción de la transformación maligna de exostosis múltiple (ME).
RESULTADOS:
De todos las 175 exostosis de 101 pacientes, 27 eran tumores de coliflor y 148 eran tumores no de forma de coliflor. De todos los 15 condrosarcomas exostotic en 15 casos, la mayoría de los tumores eran de coliflor (c2 = 38,0075, p <0,05). Tumor de coliflor para la predicción de condrosarcoma exostotic, la sensibilidad, especificidad, valor predictivo positivo, valor predictivo negativo fueron 86,7%, 84,6%, 32,5%, 98,7%, respectivamente.
CONCLUSIONES:
Tumor transformación maligna fue más frecuente en los tumores de coliflor que en los tumores no de forma de coliflor. La clasificación morfológica y la resección de prevención de los tumores de coliflor tal vez sea útil en la prevención de la transformación maligna de ME
Este artículo es originalmente publicado en:
http://www.ncbi.nlm.nih.gov/pubmed/24706308
http://www.europeanreview.org/article/7145
De:
Fan XL1, Han ZJ, Gong XY, Xiang JJ, Zhu LL, Chen WH.
Eur Rev Med Pharmacol Sci. 2014;18(6):840-5.
Todos los derechos reservados para:
Copyright © 1997-2014 European Review for Medical and Pharmacological Sciences
Abstract
AIM:
To explore the value of morphological classification in predicting malignant transformation in multiple exostoses (ME).
PATIENTS AND METHODS:
The imaging data of 116 patients (totally 190 tumors) with ME were retrospectively analyzed. All the tumors were pathology confirmed after surgical resection, including 175 exostoses from 101 patients, and 15 exostotic chondrosarcomas in 15 cases. Based on the ratio of diameter between tumor tip and tumor base (R1), tumors were classified into two types: cauliflower-like tumor (R1 ≥ 1.0) and non-cauliflower-like tumor (R1 < 1.0). In addition, non-cauliflower-like tumors were further classified into two subtypes according to the ratio of tumor height to tumor base diameter: sessile type (R2 < 1.0) and pedunculated type (R2 ≥ 1.0). The relationship between tumor shape and malignant transformation was studied.
RESULTS:
Of all the 175 exostoses from 101 patients, 27 were cauliflower-like tumors and 148 were non-cauliflower-like tumors. Of all the 15 exostotic chondrosarcomas in 15 cases, most tumors were cauliflower-like (c2 = 38.0075, p < 0.05). Cauliflower-like tumor for the prediction of exostotic chondrosarcoma, the sensibility, specificity, positive predictive value, negative predictive value were 86.7%, 84.6%, 32.5%, 98.7%, respectively.
CONCLUSIONS:
Tumor malignant transformation was more common in cauliflower-like tumors than in non-cauliflower-like tumors. The morphological classification and preventive resection of cauliflower-like tumors maybe helpful in preventing the malignant transformation of ME.
Resumen
AIM:
Para explorar el valor de clasificación morfológica en la predicción de la transformación maligna de exostosis múltiple (ME).
RESULTADOS:
De todos las 175 exostosis de 101 pacientes, 27 eran tumores de coliflor y 148 eran tumores no de forma de coliflor. De todos los 15 condrosarcomas exostotic en 15 casos, la mayoría de los tumores eran de coliflor (c2 = 38,0075, p <0,05). Tumor de coliflor para la predicción de condrosarcoma exostotic, la sensibilidad, especificidad, valor predictivo positivo, valor predictivo negativo fueron 86,7%, 84,6%, 32,5%, 98,7%, respectivamente.
CONCLUSIONES:
Tumor transformación maligna fue más frecuente en los tumores de coliflor que en los tumores no de forma de coliflor. La clasificación morfológica y la resección de prevención de los tumores de coliflor tal vez sea útil en la prevención de la transformación maligna de ME
- PMID:
- 24706308
- [PubMed - in process]
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